New developments in the pathology of malignant lymphoma: a review of the literature published from August to November 2009
نویسنده
چکیده
The pathogenesis of malignant lymphomas remains poorly understood. Several approaches to detect the genes involved are available. Bric et al. [1] focus on the detection of tumor suppressor genes by using RNA interference of specific gene products in a known mouse model for lymphoma development. They detected more than 10 new candidate tumor suppressor genes, showing the validity of their functional approach. In a similar approach in a different mouse model, Meacham et al. [2] found many new gene alterations in a mouse lymphoma, several of which involved genes associated with cell motility. They were also able to show that these genes were bona fide drug targets. Gloghini et al. [3] studied 14 cell lines and 89 lymphoma tissues for expression of histone deacetylases (HDAC). In cell lines, low expression HDAC6 was associated with growth inhibitory effects of HDAC inhibitors, but it is rarely expressed in tissue samples of diffuse large B cell lymphoma (DLBL) and Hodgkin lymphoma (HL).
منابع مشابه
New developments in the pathology of malignant lymphoma: a review of the literature published from June–August 2016
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عنوان ژورنال:
دوره 2 شماره
صفحات -
تاریخ انتشار 2009